Paloxi

PALOXI® shaft DESCRIPTION ® Paloxi (palonosetron hydrochloride) is an antiemetic and anti maladynt agent. It is a serotonin subtype 3 (5-HT3) receptor antagonist with a inviolable medical dressing affinity for this receptor. Chemically, palonosetron hydrochloride is: (3aS)-2-[(S)-1-Azabicyclo [2.2.2]oct-3-yl]-2,3,3a,4,5,6-hexahydro-1oxo-1Hbenz[de]isoquinoline hydrochloride. The empirical grammatical construction is C19H24N2O.HCl, with a molecular charge of 332.87. Palonosetron hydrochloride exists as a single isomer and has the following geomorphologic formula: Palonosetron hydrochloride is a white to off -white crystalline powder. It is freely dis oil-soluble in water, soluble in propylene glycol, and meagerly soluble in ethanol and 2 -propanol. ® Paloxi injection is a sterile, clear, colorless, non-pyrogenic, isotonic, buffered radical for intravenous ® administration. Each 5-ml vial of Paloxi injection contains 0.25 mg palonosetron base as hydrochloride, 207.5 mg mannitol, edetate disodium dihydrate, trisodium citratedihydrate, citric aci d monohydrate, and water for injection for intravenous administration. The pH of the solution is 4.5 to 5.5.

CLINICAL PHARMACOLOGY utensil of Action Palonosetron is a 5-HT3 receptor antagonist with a strong binding affinity for this receptor and litt le or no affinity for other receptors. Cancer chemotherapy may be associated with a high incidence of sickness and vomiting, particularly when certain agents, such as cisplatin, are used. 5-HT3 receptors are located on the fondness terminals of the vagus in the periphery and centrally i n the chemoreceptor cue zone of the area p! ostrema. It is thought that chemotherapeutic agents produce nausea and vomiting by releasing serotonin from the enterochromaffin cells of the small gut and that the released s erotonin then activates 5-HT3 receptors located on vagal afferents to cosmos father the vomiting reflex. Pharmacodynamics The effect of palonosetron on blood pressure, aggregate rate, and electrocardiogram parameters including QTc...If you want to get a full essay, ordinance it on our website: BestEssayCheap.com

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